Science
Foundational Research
EnzyLock is built on over $2M of foundational biomaterial research conducted in the laboratory of Prof. Anita Shukla at Brown University, one of the leading academic groups in the world working on stimuli-responsive hydrogels and infection-targeted biomaterials.
Patent Portfolio
Red Maple LifeSciences holds an exclusive option to license issued patents covering its bacteria-responsive wound dressing technology.
Preclinical data
In preclinical wound infection models, EnzyLock outperformed no treatment and a standard-of-care antimicrobial dressing on infection control and tissue healing, with healed tissue observed histologically four days after a single application. The platform works across a broad spectrum of bacteria, is non-toxic and effective with a single dose, and does not induce antimicrobial resistance.
Publications
The core bacteria-responsive platform is described in Abbasi, Akram, et al., “Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds,” Science Advances 12.12 (2026), and is protected by issued patents.
Publications
- Bacterial Enzyme-Responsive Hydrogels for Triggered Delivery of Antibiotics to Infected Wounds
- β-Lactamase-Responsive Hydrogel Drug Delivery Platform for Bacteria-Triggered Cargo Release
- β-Lactamase Triggered Visual Detection of Bacteria Using Cephalosporin Functionalized Biomaterials
- β-Lactamase-Responsive Supramolecular Hydrogels with Host-Guest Self-Healing Capability